UVP iBox Explorer² Imaging Microscope Macro to Micro Fluorescent In Vivo Small Animal Imaging

  • Easy transition from the macroscopic to the microscope scale

  • Visualize micro injection of cancer cells in vivo

  • Ability to image organs and cells subcutaneously and within the body cavity of living mice

  • Optical configurations are parcentered and parfocal

Product details

Now researchers can take detection of fluorescent markers in small animals to a new level with the iBox Explorer² Imaging Microscope! The iBox Explorer² is unique in its ability to view macro to micro in the whole animal to individual cell, subcutaneously and within the body cavity of mice. The upright optics provide an ultra long working distance and high numerical aperture (NA) for detailed fluorescent in vivo imaging.

The UVP iBox Explorer² easily detects GFP/RFP and other fluorescent markers in small animals. The capabilities of this in vivo small animal imaging system enables research studies in whole animal down to individual cells.

Focusing on Fluorescent Cancer Cell Detection
In research performed, HT1080 fluorescent cancer cells were injected into the epigastrica cranialis. Immediately after the injection, the fluorescence indicates the cells escaped around the injection sites. In the zoomed in views, a cluster of cancer cells can be observed in the blood stream.

System Capabilities

  • Capture images with a superior cooled CCD camera and optics that are optimized for VIS - NIR imaging
  • View the whole animal to the single cell level via the motorized optics
  • Seamlessly navigate the image through all magnification ranges from 0.17x to 16.5x
  • Control eLITE excitation filters and light intensity via the software interface
  • Generate continuous excitation spectrum with the configurable filters for fluorescence microscopy
  • Slide-out warming plate maintains uniform temperature
  • Create optimum imaging conditions with the light tight darkroom
  • See quick sample inspection with unique viewing window
  • Simply adjust the position of the motorized X, Y, Z stage with the joystick

Technical Data

Specifications/features

UVP iBox® Explorer²™ Imaging Microscope

Darkroom Specifications
Emission FiltersFour-position interchangeable rack:
  • 515nm Longpass, GFP, RFP, Neutral Density

  • Additional wavelength filters available

 
ControlsAutomated, software controlled
TravelPrecision motorized X, Y, Z
ResolutionX=10μm, Y=10μm, Z=1μm
Position/FocusControlled by joystick/software
Warming Plate37°C, user adjustable
Darkroom Dimensions17.5"W x 19.5"D x 41"H (44.5 x 49.5 x 104cm)
Light Sources150 watt Xenon
Fiber OpticCoaxial and epi illumination with light heads mounted to the darkroom
Excitation FiltersEight position wheel includes filters - GFP, RFP (others available)
ControlsVia software
eLITE Dimensions12.5 x 13.5 x 10 in. (31.8 x 34.3 x 25.4cm)
eLITE Dimensions12.5 x 13.5 x 10 in. (31.8 x 34.3 x 25.4cm)
Camera
OptiChemi 615
 
  • Monochrome

  • 16 bit

  • 2184 x 1472 pixel Resolution

  • 3.2, extendable to 9.6 Megapixels

  • Cooling: -60°C from ambient

  • Peak QE: 88% (quantum efficiency)

 
Software

 

Interface

  • Camera, objectives, darkroom, eLITE

Tools

  • Macros and templates

Analysis

  • Extensive functions including area density measurements, volume measurements and tumor sizing

Documentation

  • Create reports and export data

Compliance

  • Supports 21 CFR Part 11

UVP’s software requires Microsoft Windows 7,8, or 10 (32-bit or 64-bit).

Magnification and Imaging Area

Optical Magnification:
0.17x0.25x0.5x1.66x2.5x4.5x7.5x8.8x16.5x
FOV Observation Range:
90x90mm60x60mm30x30mm9x9mm6x6mm3.3x3.3mm2x2mm1.7x1.7mm0.9x0.9mm

 

Order Information

Order numberDescription
97-0595-01UVP iBox Explorer2  with Optichemi 615 Camera

 

Downloads

UVP iBox® Explorer2 Brochure

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